Health Top Stories

Protect Children First with H1N1 Flu Vaccine, Says National Pediatric Disease Expert

The optimal way to control swine flu, the new H1N1 virus that emerged as a global threat in 2009, is to vaccinate children with the planned H1N1 flu shot, says the co-director of the University of Alabama at Birmingham (UAB) Division of Pediatric Infectious Diseases. ?Children are the highest-risk group for spreading the virus among themselves, and as a consequence, spreading it around their community,? says UAB?s David Kimberlin, M.D., one of four U.S. physicians serving on the federal Safety Monitoring Committee reviewing clinical trials of H1N1 vaccines. The committee is a part of the Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases. ?Like a bull?s-eye, the middle of the target is what you vaccinate so you don?t see infections in the concentric rings around the center,? Kimberlin says. ?The center of the protection bull?s-eye should be children.? More »

Most would refuse emergency use H1N1 vaccine or additive

A majority of Americans would not take an H1N1 flu vaccine or drug additive authorized for emergency use by the Food and Drug Administration, according to a University of Pittsburgh Graduate School of Public Health and University of Georgia study. The study, available online today in Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, found that fewer than 10 percent of those surveyed said they would be willing to take such a vaccine or drug and nearly 30 percent remained undecided. The passage of the Project Bioshield Act in 2004 created the emergency use authorization (EUA) giving the FDA the ability to use experimental or ?off label? drugs in the event of an actual or potential emergency. To date, four vaccines against H1N1 virus have been approved under the same process used by the FDA for the seasonal flu vaccine. Also, several drug additives, or adjuvants ? sometimes added to vaccines to strengthen the immune response and stretch the quantity of available vaccines in the event of a pandemic ? have been ordered and stockpiled by the federal government in case they may be needed. But adding them to H1N1 vaccines would trigger an EUA, which is one of the reasons the federal government has chosen not to use them. ?Although the U.S government has held off on including an adjuvant in H1N1 vaccines for now, American officials may need to reconsider this decision as the pandemic unfolds,? said study author Sandra Quinn, Ph.D., associate dean for Student Affairs and Education and associate professor at the University of Pittsburgh Graduate School of Public Health. ?There also remains a significant shortage of the vaccines in many countries around the world. Given this, our finding that few people would accept a new but not yet fully approved H1N1 vaccine or drug is very worrisome,? she said.  More »

One in Eight Strokes Is Preceded by ?Warning Stroke?

One out of every eight strokes is preceded by a ?warning stroke,? which is a transient ischemic attack (TIA) or mild stroke, according to research published in the September 29, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology. ?These results illustrate the need for better risk assessment tools for preventing strokes before they occur,? said study author Daniel G. Hackam, MD, PhD, of the University of Western Ontario in London, ON. ?Other studies have shown that up to 80 percent of strokes after TIA can be prevented when risk factors are managed intensively.? For the study, researchers identified all people at Ontario hospitals with a diagnosis of stroke over four years. Of the 16,400 patients, 2,032, or 12.4 percent, had a TIA prior to the stroke. During a TIA, stroke symptoms last for less than 24 hours and then resolve. More »