Cancer

High Serum Insulin Levels And Risk Of Prostate Cancer

Elevated insulin levels in the normal range appear to be associated with an increased risk of prostate cancer, according to a new study published online August 21 in the Journal of the National Cancer Institute. Insulin-like growth factors appear to be involved in the development of prostate cancer, but the relationship between circulating insulin levels and prostate cancer risk has been unclear. Demetrius Albanes, M.D., of the Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics at the National Cancer Institute in Bethesda, Md., and colleagues investigated the relationship of the level of serum insulin and glucose, as well as surrogate indices of insulin resistance, to the development of prostate cancer. Rese... More »

Gen-Probe Begins U.S. Clinical Study Of PROGENSA PCA3 Assay, New Molecular Test To Help Assess Prostate Cancer Risk

Gen-Probe Incorporated announced that the Company has begun a clinical trial intended to secure U.S. regulatory approval of its PROGENSA PCA3 assay, a new molecular test that may help determine the need for a repeat prostate biopsy. "Based on the results of our extensive clinical research studies and our European commercial experience, we believe that our PROGENSA PCA3 assay can help predict the risk of a positive follow-up biopsy, thereby improving patient care," said Eric Lai, PhD, Gen-Probe's senior vice president of research and development. "In addition, this is an important step forward in our efforts to maximize the economic value of our oncology strategy." The clinical study of the PROGENSA PCA3 assay is expected to conclude i... More »

New Prognostic Marker For Human Breast Cancer

Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are associated with unfavorable prognosis and progressive stages of disease. Researchers writing in the open access journal BMC Cancer found increased expression of GLI1 in samples taken from more advanced and less survivable tumors. Edgar Dahl led a team of researchers from RWTH Aachen's University Hospital who sought to evaluate whether GLI1 could represent a new prognostic marker in breast cancer treatment. He said, "GLI1, a mediator of the so-called 'hedgehog' signaling pathway, has previously been implicated in the development of different human tumor entities. We've found a positive, significant association between overexpression of GLI1 a... More »

New Breast Cancer Study Findings Recently Were Reported By Researchers At Harvard University

According to recent research from the United States, "A diagnosis of metastatic breast cancer (BC) forces patients and providers to make difficult treatment decisions. To pilot test a decision aid (DA) for advanced BC. Pretest, posttest study." "Two academic cancer centers in Boston, Massachusetts. Fifty patients diagnosed with advanced BC. A patient DA that consisted of a 30-minute DVD and booklet. Patients were surveyed at baseline, after the intervention, and at 3 months. included use and acceptability of DA, distress, treatment goals, and preference for and actual participation in decisions. Physicians were surveyed at baseline and 3 months. included treatment goals, assessment of patients' experience with treatments, and patients' p... More »

Human Trials With Kanzius Invention Could Start In 2011: Liver, Pancreatic Cases To Go First

Pancreatic and liver cancer patients would be the first people treated with the late John Kanzius' external radio wave generator if it's approved by the U.S. Food and Drug Administration. Human trials for Kanzius' experimental cancer treatment device could get under way as early as 2011, said Steven Curley, M.D., lead investigator for the Kanzius project at M.D. Anderson Cancer Center in Houston. "Why those two cancers? We have antibodies that we know will attach to those cancer cells and not other, healthy cells," Curley said. "They are also two of the worst types of cancers. ... Ninety-six percent to 97 percent of people with these cancers die from the disease." Curley spoke for about an hour Friday morning at a special Eggs 'n'... More »